Concordance of pcr and early thorax computed tomography findings in covid-19 patients

Abstract

Aim: The aim of this study was to investigate concordance between polymerase chain reaction (PCR) test results and early thorax computed tomography (CT) findings of the patients in whom coronavirus disease 2019 (COVID-19) was suspected after evaluation of their complaints and physical examination findings. Material and Methods: One hundred and fourteen patients with suspicion of COVID-19, evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) existence with PCR test and performed thorax CT in the first 48 hours, between April and July 2020, were enrolled in this study retrospectively. Demographic characteristics, laboratory parameters and thorax CT findings of PCR positive and negative patients were compared. If patients had negative PCR test results, but clinical suspicion for COVID-19 persisted, additional PCR samples were tested at 48-hour intervals. Results: Interlobular septal thickening was more frequent in PCR positive patients (p=0.043). There was no significant thorax CT finding in 16 (28.6%) PCR positive and 14 (24.1%) PCR negative patients. Bilateral, peripheral and multilobar ground glass opacifications, consolidation and interlobular septal thickening were the most frequent findings in both groups. Neutrophil (p<0.001) and platelet counts (p=0.038) were significantly lower in PCR positive group. Conclusion: The thorax CT findings of the patients whose PCR tests were positive or negative were greatly similar except for interlobular septal thickening, thus thorax CT should not be used alone in the diagnosis of COVID-19 especially in early stages. In decision making, symptoms, laboratory and CT findings and PCR tests of patients must be evaluated all together. © 2020, Duzce University Medical School. All rights reserved.