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Effects of endothelin receptor blockade and COX inhibition on intestinal I/R injury in a rat model: Experimental research.
Ucar, Bercis Imge; Erikci, Acelya; Kosemehmetoglu, Kemal; Ozkul, Ceren; Iskit, Alper Bektas; Ucar, Gulberk; Zeren, Sezgin (Tıp Fakültesi, 2020-11-01)Background: Intestinal ischemia is a highly morbid and mortal condition with no specific treatment. The present study aimed to investigate the effects of cyclooxygenase (COX) inhibition synchronized with nitric oxide (NO) ... -
Gas chromatography-mass spectrometry based O stable isotope labeling of Krebs cycle intermediates.
Eylem, Cemil Can; Baysal, Ipek; Erikci, Acelya; Yabanoglu-Ciftci, Samiye; Zhang, Song; Kir, Sedef; Terzic, Andre; Dzeja, Petras; Nemutlu, Emirhan (Ezcacılık Fakültesi, 2021-04-15)New technologies permit determining metabolomic profiles of human diseases by fingerprinting metabolites levels. However, to fully understand metabolomic phenotypes, metabolite levels and turnover rates are necessary to ... -
Polymeric Nanoparticle Versus Liposome Formulations: Comparative Physicochemical and Metabolomic Studies as L-Carnitine Delivery Systems.
Yaşacan, Merve; Erikçi, Açelya; Eylem, Cemil Can; Çiftçi, Samiye Yabanoğlu; Nemutlu, Emirhan; Ulubayram, Kezban; Eroğlu, İpek (Ezcacılık Fakültesi, 2020-11-06)L-Carnitine has attracted much more attention especially in the treatment of crucial diseases such as diabetes, regional slimming, and obesity because of its metabolic activities. However, because of its short half-life, ... -
Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors.
Ozdemir, Zeynep; Alagoz, Mehmet Abdullah; Uslu, Harun; Karakurt, Arzu; Erikci, Acelya; Ucar, Gulberk; Uysal, Mehtap (Ezcacılık Fakültesi, 2020-06-01)Background: Since brain neurotransmitter levels are associated with the pathology of various neurodegenerative diseases like Parkinson and Alzheimer, monoamineoxidase (MAO) plays a critical role in balancing these ...
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